Bos taurus Gene: BT.76143 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-633868.3 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | BT.76143 | ||||||||||||||||||||||||||
Gene Name | E3 ubiquitin-protein ligase CHIP | ||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000019136 | ||||||||||||||||||||||||||
Encoded Proteins |
STIP1 homology and U box-containing protein 1
STIP1 homology and U box-containing protein 1
|
||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] STUB1 facilitates the formation of a TLR signalling complex by recruiting, ubiquitinating, and activating Src and PRKCZ. Knockdown of Stub1 in mice inhibits Tlr4- and Tlr9-signalling pathways. (Demonstrated in mice)
[Mus musculus] Stub1 facilitates the formation of a TLR signalling complex by recruiting, ubiquitinating, and activating Src and Prkcz. Knockdown of Stub1 inhibits Tlr4- and Tlr9-signalling pathways.
|
||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103266:
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009] This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014] |
||||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 25:558378-560734 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
|
||||||||||||||||||||||||||
REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
Signaling by ERBB2 pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
Signaling by ERBB2 pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Immune System pathway
TGF-beta receptor signaling activates SMADs pathway
Loss of Function of TGFBR2 in Cancer pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Adaptive Immune System pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
|
||||||||||||||||||||||||||
KEGG |
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
|
||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||
PID NCI |
Alpha-synuclein signaling
|
||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | F1MUH4 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 504565 | ||||||||||||||||||||||||||
UniGene | Bt.76143 | ||||||||||||||||||||||||||
RefSeq | NM_001075166 XM_005224392 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | DAAA02057282 | ||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | 504565 | ||||||||||||||||||||||||||