Version 5.4
Bos taurus Gene: BT.35140
Summary
InnateDB Gene IDBG-634106.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.35140
Gene Name tripeptidyl-peptidase 1 precursor
Synonyms CLN2; TPP-1; TPP-I
Species Bos taurus
Ensembl Gene ENSBTAG00000015403
Encoded Proteins
IDBP-685866
tripeptidyl-peptidase 1 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166340:
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:47065387-47070711
Strand Forward strand
Band
Transcripts
ENSBTAT00000020469 ENSBTAP00000020469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008240 tripeptidyl-peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0007040 lysosome organization
GO:0007399 nervous system development
GO:0030855 epithelial cell differentiation
GO:0043171 peptide catabolic process
GO:0045453 bone resorption
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000166340
View Gene Order
ENSMUSG00000030894
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
KEGG
hsa04142
Lysosome pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MK08
UniProt Splice Variant
Entrez Gene 515575
UniGene Bt.35140
RefSeq NM_001075718
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02040852 DAAA02040853
GenPept
RNA Seq Atlas 515575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca