InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.41610

Summary

InnateDB Gene

IDBG-634111.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.41610

Gene Name

2'-5'-oligoadenylate synthase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014628

Encoded Proteins

IDBP-685876

2'-5'-oligoadenylate synthase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21190483

[Homo sapiens] OAS2 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the OAS2 activates RNASEL to cleave ssRNA. The OAS/RNASEL pathway triggers the RIG-I pathway and induce IFNB production.

PMID 21190483

[Mus musculus] Oas2 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas2 activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111335:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2\'-specific nucleotidyl transfer reactions to synthesize 2\',5\'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:63611774-63640159

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019477

ENSBTAP00000019477

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001730	2'-5'-oligoadenylate synthetase activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0002376	immune system process
GO:0006164	purine nucleotide biosynthetic process
GO:0006401	RNA catabolic process
GO:0006486	protein glycosylation
GO:0006955	immune response
GO:0009615	response to virus
GO:0018377	protein myristoylation
GO:0045087	innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm