InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TAF10

Summary

InnateDB Gene

IDBG-634118.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF10

Gene Name

transcription initiation factor TFIID subunit 10

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000694

Encoded Proteins

IDBP-685871

transcription initiation factor TFIID subunit 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166337:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:47073272-47074686

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000926

ENSBTAP00000000926

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0070063	RNA polymerase binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0016578	histone deubiquitination
GO:0043966	histone H3 acetylation
GO:0051260	protein homooligomerization

Cellular Component

GO:0000125	PCAF complex
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0048471	perinuclear region of cytoplasm