InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPM2A

Summary

InnateDB Gene

IDBG-634153.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPM2A

Gene Name

laforin

Synonyms

laforin

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015181

Encoded Proteins

IDBP-685909

laforin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112425:
This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:84028748-84136430

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020200

ENSBTAP00000020200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0019203	carbohydrate phosphatase activity
GO:0030246	carbohydrate binding
GO:2001070	starch binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007399	nervous system development
GO:0016311	dephosphorylation
GO:0046855	inositol phosphate dephosphorylation
GO:0046959	habituation