Homo sapiens Gene: TLN1
Summary
InnateDB Gene IDBG-63416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLN1
Gene Name talin 1
Synonyms ILWEQ; TLN;
Species Homo sapiens
Ensembl Gene ENSG00000137076
Encoded Proteins
talin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35696948-35732395
Strand Reverse strand
Band p13.3
Transcripts
ENST00000378192
ENST00000314888 ENSP00000316029
ENST00000489255
ENST00000464379
ENST00000466916
ENST00000465002
ENST00000486788
ENST00000495712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 52 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0017166 vinculin binding
GO:0030274 LIM domain binding
GO:0032403 protein complex binding
GO:0051015 actin filament binding
Biological Process
GO:0002576 platelet degranulation
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007043 cell-cell junction assembly
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0030866 cortical actin cytoskeleton organization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0001726 ruffle
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TSLP pathway
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Developmental Biology pathway
Semaphorin interactions pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
XBP1(S) activates chaperone genes pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Smooth Muscle Contraction pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Metabolism of proteins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Platelet Aggregation (Plug Formation) pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Muscle contraction pathway
Hemostasis pathway
KEGG
Focal adhesion pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Ucalpain and friends in cell spread [Biocarta view]
Integrin signaling pathway [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
PID NCI
Integrins in angiogenesis
Nectin adhesion pathway
Signaling events mediated by focal adhesion kinase
Alpha4 beta1 integrin signaling events
RhoA signaling pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.471014 Hs.600368 Hs.623659
RefSeq NM_006289 XM_005251564 XM_006716852
HUGO
OMIM
CCDS CCDS35009
HPRD 01726
IMGT
EMBL
GenPept
RNA Seq Atlas