InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TLN1

Summary

InnateDB Gene

IDBG-63416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLN1

Gene Name

talin 1

Synonyms

ILWEQ; TLN

Species

Homo sapiens

Ensembl Gene

ENSG00000137076

Encoded Proteins

IDBP-63420

talin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:35696948-35732395

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000378192
ENST00000314888	ENSP00000316029
ENST00000489255
ENST00000464379
ENST00000466916
ENST00000465002
ENST00000486788
ENST00000495712

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	52 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005158	insulin receptor binding
GO:0005178	integrin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0017166	vinculin binding
GO:0030274	LIM domain binding
GO:0032403	protein complex binding
GO:0051015	actin filament binding

Biological Process

GO:0002576	platelet degranulation
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007043	cell-cell junction assembly
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030866	cortical actin cytoskeleton organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome