InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CDH3

Summary

InnateDB Gene

IDBG-634205.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH3

Gene Name

Cadherin-3

Synonyms

CDH15

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033248

Encoded Proteins

IDBP-686022

Cadherin-3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000062038:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:36095734-36140923

Strand

Forward strand

Band

Transcripts

ENSBTAT00000045591

ENSBTAP00000042970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001895	retina homeostasis
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0010628	positive regulation of gene expression
GO:0010838	positive regulation of keratinocyte proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0022405	hair cycle process
GO:0031424	keratinization
GO:0032773	positive regulation of monophenol monooxygenase activity
GO:0032912	negative regulation of transforming growth factor beta2 production
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0048023	positive regulation of melanin biosynthetic process
GO:0051796	negative regulation of catagen
GO:0060070	canonical Wnt signaling pathway
GO:0060901	regulation of hair cycle by canonical Wnt signaling pathway
GO:1902910	positive regulation of melanosome transport