InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PHGDH

Summary

InnateDB Gene

IDBG-634247.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHGDH

Gene Name

D-3-phosphoglycerate dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039719

Encoded Proteins

IDBP-686010

D-3-phosphoglycerate dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092621:
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:23672339-23703529

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008907

ENSBTAP00000008907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004617	phosphoglycerate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0048037	cofactor binding
GO:0051287	NAD binding

Biological Process

GO:0006541	glutamine metabolic process
GO:0006544	glycine metabolic process
GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0006566	threonine metabolic process
GO:0008152	metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009448	gamma-aminobutyric acid metabolic process
GO:0010468	regulation of gene expression
GO:0019530	taurine metabolic process
GO:0021510	spinal cord development
GO:0021782	glial cell development
GO:0021915	neural tube development
GO:0022008	neurogenesis
GO:0031175	neuron projection development
GO:0055114	oxidation-reduction process
GO:0070314	G1 to G0 transition