InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.11497

Summary

InnateDB Gene

IDBG-634344.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.11497

Gene Name

serine/threonine-protein kinase VRK1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014230

Encoded Proteins

IDBP-686118

serine/threonine-protein kinase VRK1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100749:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:63297840-63343901

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018916

ENSBTAP00000018916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031493	nucleosomal histone binding
GO:0035175	histone kinase activity (H3-S10 specific)
GO:0072354	histone kinase activity (H3-T3 specific)

Biological Process

GO:0006468	protein phosphorylation
GO:0043987	histone H3-S10 phosphorylation
GO:0046777	protein autophosphorylation
GO:0072355	histone H3-T3 phosphorylation
GO:0090166	Golgi disassembly