InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BCL11B

Summary

InnateDB Gene

IDBG-634348.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL11B

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018019

Encoded Proteins

IDBP-686121

B-cell CLL/lymphoma 11B (zinc finger protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25964371

[Mus musculus] Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the group 2 innate lymphoid cells (ILC2) lineage and is required for ILC2 development.

PMID 25964370

[Mus musculus] Bcl11b is a factor in the differentiation of group 2 innate lymphoid cells (ILC2s).

PMID 26231117

[Mus musculus] Bcl11b sustains the genetic and functional programs, as well as lineage fidelity, of mature type 2 innate lymphoid cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127152:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:65841997-65938304

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023987

ENSBTAP00000023987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0003334	keratinocyte development
GO:0003382	epithelial cell morphogenesis
GO:0007409	axonogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0010837	regulation of keratinocyte proliferation
GO:0019216	regulation of lipid metabolic process
GO:0021773	striatal medium spiny neuron differentiation
GO:0021953	central nervous system neuron differentiation
GO:0031077	post-embryonic camera-type eye development
GO:0033077	T cell differentiation in thymus
GO:0033153	T cell receptor V(D)J recombination
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043066	negative regulation of apoptotic process
GO:0043368	positive T cell selection
GO:0043588	skin development
GO:0045664	regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046632	alpha-beta T cell differentiation
GO:0048538	thymus development
GO:0071678	olfactory bulb axon guidance

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000127152

View Gene Order

ENSMUSG00000048251

View Gene Order

Cross-References

SwissProt

TrEMBL

E1BD25

UniProt Splice Variant

Entrez Gene

783269

UniGene

RefSeq

XM_001251908 XM_002696767 XM_005196318 XM_005222295

HUGO

HGNC:13222

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02053212

GenPept

RNA Seq Atlas

783269