InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VPS4A

Summary

InnateDB Gene

IDBG-634371.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS4A

Gene Name

vacuolar protein sorting-associated protein 4A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001659

Encoded Proteins

IDBP-686220

vacuolar protein sorting 4 homolog A

IDBP-686241

vacuolar protein sorting 4 homolog A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132612:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:36584633-36595360

Strand

Forward strand

Band

Transcripts

ENSBTAT00000045547	ENSBTAP00000042928
ENSBTAT00000065503	ENSBTAP00000055660

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity