Version 5.4
| Bos taurus Gene: POLD2 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-634379.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | POLD2 | ||||||||||||
| Gene Name | DNA polymerase delta subunit 2 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000012241 | ||||||||||||
| Encoded Proteins |
DNA polymerase delta subunit 2
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106628:
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012] This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 4:77873883-77881765 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
S Phase pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Extension of Telomeres pathway
Transcription-coupled NER (TC-NER) pathway
Removal of the Flap Intermediate from the C-strand pathway
DNA Replication pathway
Telomere Maintenance pathway
Polymerase switching on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of the Flap Intermediate pathway
Nucleotide Excision Repair pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Processive synthesis on the lagging strand pathway
Processive synthesis on the C-strand of the telomere pathway
Synthesis of DNA pathway
Cell Cycle pathway
DNA Repair pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Lagging Strand Synthesis pathway
Mismatch Repair pathway
Removal of DNA patch containing abasic residue pathway
Base Excision Repair pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA strand elongation pathway
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| KEGG | |||||||||||||
| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Polymerase switching on the C-strand of the telomere pathway
Removal of the Flap Intermediate from the C-strand pathway
Processive synthesis on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Removal of the Flap Intermediate pathway
Processive synthesis on the lagging strand pathway
Polymerase switching pathway
Leading Strand Synthesis pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Removal of DNA patch containing abasic residue pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
DNA Replication pathway
Synthesis of DNA pathway
Resolution of Abasic Sites (AP sites) pathway
S Phase pathway
Chromosome Maintenance pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Base Excision Repair pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Processive synthesis on the lagging strand pathway
Transcription-coupled NER (TC-NER) pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Removal of the Flap Intermediate from the C-strand pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Removal of DNA patch containing abasic residue pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Polymerase switching pathway
Processive synthesis on the C-strand of the telomere pathway
Lagging Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
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| KEGG |
Pyrimidine metabolism pathway
DNA replication pathway
Purine metabolism pathway
Nucleotide excision repair pathway
Homologous recombination pathway
Mismatch repair pathway
Base excision repair pathway
Pyrimidine metabolism pathway
DNA replication pathway
Purine metabolism pathway
Nucleotide excision repair pathway
Homologous recombination pathway
Base excision repair pathway
Mismatch repair pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | |||||||||||||
| UniGene | Bt.5282 | ||||||||||||
| RefSeq | NM_174428 XM_005205574 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | |||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | |||||||||||||