Version 5.4
Bos taurus Gene: BT.37226
Summary
InnateDB Gene IDBG-634399.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.37226
Gene Name fibroblast growth factor 12
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012413
Encoded Proteins
IDBP-686183
fibroblast growth factor 12
IDBP-686186
fibroblast growth factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114279:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:75616651-75895219
Strand Forward strand
Band
Transcripts
ENSBTAT00000016471 ENSBTAP00000016471
ENSBTAT00000046189 ENSBTAP00000043510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0008543 fibroblast growth factor receptor signaling pathway
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114279
View Gene Order
ENSMUSG00000022523
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
mmu05218
Melanoma pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BLM4 F1MFC0
UniProt Splice Variant
Entrez Gene 615823
UniGene Bt.37226
RefSeq NM_001079789 XM_005201557 XM_005201556
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001757 DAAA02001758 DAAA02001759 DAAA02001760 DAAA02001761 DAAA02001762
GenPept
RNA Seq Atlas 615823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca