InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: INHBA

Summary

InnateDB Gene

IDBG-634513.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHBA

Gene Name

Inhibin beta A chain

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002912

Encoded Proteins

IDBP-686292

Inhibin beta A chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122641:
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:79986254-79997754

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003783

ENSBTAP00000003783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0017046	peptide hormone binding
GO:0042802	identical protein binding
GO:0070699	type II activin receptor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001541	ovarian follicle development
GO:0001707	mesoderm formation
GO:0001942	hair follicle development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030308	negative regulation of cell growth
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032924	activin receptor signaling pathway
GO:0035987	endodermal cell differentiation
GO:0040007	growth
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0042541	hemoglobin biosynthetic process
GO:0042701	progesterone secretion
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046880	regulation of follicle-stimulating hormone secretion
GO:0048333	mesodermal cell differentiation
GO:0060021	palate development
GO:0060279	positive regulation of ovulation
GO:0061029	eyelid development in camera-type eye
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand