InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CLDN1

Summary

InnateDB Gene

IDBG-634518.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN1

Gene Name

Claudin-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013148

Encoded Proteins

IDBP-686302

Claudin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163347:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:77596386-77611958

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017476

ENSBTAP00000017476

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016338	calcium-independent cell-cell adhesion
GO:0045216	cell-cell junction organization
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction