InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NCK2

Summary

InnateDB Gene

IDBG-634552.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCK2

Gene Name

cytoplasmic protein NCK2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015205

Encoded Proteins

IDBP-686334

cytoplasmic protein NCK2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071051:
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:45780703-45829966

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020230

ENSBTAP00000020230

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007015	actin filament organization
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter