Bos taurus Gene: SIKE1 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-634688.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | SIKE1 | ||||||
Gene Name | Suppressor of IKBKE 1 | ||||||
Synonyms | SIKE | ||||||
Species | Bos taurus | ||||||
Ensembl Gene | ENSBTAG00000015977 | ||||||
Encoded Proteins |
Suppressor of IKBKE 1
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
InnateDB Annotation from Orthologs | |||||||
Summary |
[Homo sapiens] RP5-1000E10.4 (SIKE) is a physiological suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF3 but not NF-kappaB activation pathways.
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Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000052723:
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 3:28665527-28671398 | ||||||
Strand | Forward strand | ||||||
Band | |||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||
NETPATH | |||||||
REACTOME |
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
TRAF3-dependent IRF activation pathway pathway
TRAF6 mediated IRF7 activation pathway
Innate Immune System pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
TRAF6 mediated IRF7 activation pathway
TRAF3-dependent IRF activation pathway pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Innate Immune System pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRAF3-dependent IRF activation pathway pathway
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KEGG |
RIG-I-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
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INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Bt.20253 | ||||||
RefSeq | NM_001075281 XM_005204011 | ||||||
HUGO | |||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||