InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NTHL1

Summary

InnateDB Gene

IDBG-634995.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTHL1

Gene Name

Endonuclease III-like protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006272

Encoded Proteins

IDBP-686793

Endonuclease III-like protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065057:
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:1590252-1595934

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000049780

ENSBTAP00000046623

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003824	catalytic activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016829	lyase activity
GO:0019104	DNA N-glycosylase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006974	cellular response to DNA damage stimulus
GO:0008152	metabolic process