Version 5.4
Bos taurus Gene: RAP1A
Summary
InnateDB Gene IDBG-635053.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP1A
Gene Name Ras-related protein Rap-1A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014710
Encoded Proteins
IDBP-686856
Ras-related protein Rap-1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116473:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:31746448-31764423
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019575 ENSBTAP00000019575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008565 protein transporter activity
GO:0017016 Ras GTPase binding
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0032403 protein complex binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0010976 positive regulation of neuron projection development
GO:0015031 protein transport
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0038180 nerve growth factor signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000116473
View Gene Order
ENSMUSG00000068798
View Gene Order
Pathways
NETPATH
REACTOME
REACT_227719
ARMS-mediated activation pathway
REACT_218381
Signalling to ERKs pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_211156
Prolonged ERK activation events pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_217101
Integration of energy metabolism pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_217199
Platelet Aggregation (Plug Formation) pathway
REACT_214353
Signal Transduction pathway
REACT_221144
p130Cas linkage to MAPK signaling for integrins pathway
REACT_223002
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_206808
Integrin alphaIIb beta3 signaling pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_219139
Metabolism pathway
REACT_217846
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_207066
Signalling by NGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_214141
Rap1 signalling pathway
REACT_217712
Frs2-mediated activation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_11061
Signalling by NGF pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_262560
Frs2-mediated activation pathway
REACT_237855
Rap1 signalling pathway
REACT_231290
Signalling to ERKs pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_234035
ARMS-mediated activation pathway
REACT_188257
Signal Transduction pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_248547
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04972
Pancreatic secretion pathway
mmu05211
Renal cell carcinoma pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04972
Pancreatic secretion pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
pi3kcipathway
Class I PI3K signaling events
reelinpathway
Reelin signaling pathway
tcr_pathway
TCR signaling in naïve CD4+ T cells
epopathway
EPO signaling pathway
ret_pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt P62833
TrEMBL
UniProt Splice Variant
Entrez Gene 282031
UniGene Bt.10622
RefSeq NM_174448
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134566 J04196
GenPept AAA30415 AAI34567
RNA Seq Atlas 282031

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca