InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRIM27

Summary

InnateDB Gene

IDBG-635228.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM27

Gene Name

zinc finger protein RFP

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000871

Encoded Proteins

IDBP-687052

zinc finger protein RFP

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM27 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204713:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:29906624-29920511

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001158

ENSBTAP00000001158

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.

Predicted by orthology
Total	82 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002820	negative regulation of adaptive immune response
GO:0006469	negative regulation of protein kinase activity
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032897	negative regulation of viral transcription
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0042147	retrograde transport, endosome to Golgi
GO:0045087	innate immune response
GO:0045814	negative regulation of gene expression, epigenetic
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206	protein trimerization
GO:0070534	protein K63-linked ubiquitination
GO:0072643	interferon-gamma secretion
GO:0090281	negative regulation of calcium ion import
GO:1900041	negative regulation of interleukin-2 secretion
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0030904	retromer complex
GO:0031965	nuclear membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000204713

View Gene Order

ENSMUSG00000021326

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.21774

RefSeq

NM_001075799

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas