Bos taurus Gene: TRIM27
InnateDB Gene IDBG-635228.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM27
Gene Name zinc finger protein RFP
Species Bos taurus
Ensembl Gene ENSBTAG00000000871
Encoded Proteins
zinc finger protein RFP
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
[Homo sapiens] TRIM27 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204713:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:29906624-29920511
Strand Forward strand
ENSBTAT00000001158 ENSBTAP00000001158
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002820 negative regulation of adaptive immune response
GO:0006469 negative regulation of protein kinase activity
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032897 negative regulation of viral transcription
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0042147 retrograde transport, endosome to Golgi
GO:0045087 innate immune response
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206 protein trimerization
GO:0070534 protein K63-linked ubiquitination
GO:0072643 interferon-gamma secretion
GO:0090281 negative regulation of calcium ion import
GO:1900041 negative regulation of interleukin-2 secretion
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0030904 retromer complex
GO:0031965 nuclear membrane
Homo sapiens
Mus musculus
Gene ID
Gene Order
UniProt Splice Variant
Entrez Gene
UniGene Bt.21774
RefSeq NM_001075799
RNA Seq Atlas