InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHD3

Summary

InnateDB Gene

IDBG-635308.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD3

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014377

Encoded Proteins

IDBP-687256

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170004:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:28185822-28206741

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019119

ENSBTAP00000019119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006325	chromatin organization
GO:0006333	chromatin assembly or disassembly
GO:0006355	regulation of transcription, DNA-templated
GO:0007051	spindle organization
GO:0008152	metabolic process
GO:0051297	centrosome organization