InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SHMT2

Summary

InnateDB Gene

IDBG-635321.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHMT2

Gene Name

Serine hydroxymethyltransferase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031500

Encoded Proteins

IDBP-687155

Serine hydroxymethyltransferase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182199:
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:56539303-56544574

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000038244

ENSBTAP00000038059

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003824	catalytic activity
GO:0004372	glycine hydroxymethyltransferase activity
GO:0016740	transferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006544	glycine metabolic process
GO:0006563	L-serine metabolic process
GO:0006730	one-carbon metabolic process
GO:0035999	tetrahydrofolate interconversion

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome