Bos taurus Gene: CHST8
Summary
InnateDB Gene IDBG-635340.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHST8
Gene Name carbohydrate sulfotransferase 8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047670
Encoded Proteins
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124302:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:44305869-44378890
Strand Forward strand
Band
Transcripts
ENSBTAT00000064164 ENSBTAP00000056551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006790 sulfur compound metabolic process
GO:0016051 carbohydrate biosynthetic process
GO:0030166 proteoglycan biosynthetic process
GO:0042446 hormone biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Cross-References
SwissProt
TrEMBL C0LMH8
UniProt Splice Variant
Entrez Gene 100271926
UniGene Bt.96718
RefSeq NM_001145992 XM_005218898
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046887 DAAA02046888 DAAA02046889 FJ744152
GenPept ACN62563
RNA Seq Atlas 100271926