Bos taurus Gene: GNAI3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-635365.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | GNAI3 | ||||||||||||||||||||||
Gene Name | guanine nucleotide-binding protein G(k) subunit alpha | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000013016 | ||||||||||||||||||||||
Encoded Proteins |
guanine nucleotide-binding protein G(k) subunit alpha
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] GNAI3 is a G protein involved in autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (CCDC88A) and GDI inhibitor (GPSM1). During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.
[Mus musculus] Gnai3 is a G protein involved in anti-autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (Ccdc88a) and GDI inhibitor (Gpsm1). During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signalling pathways.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065135:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 3:33969546-34013930 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TSH pathway
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REACTOME |
ADP signalling through P2Y purinoceptor 12 pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Adenylate cyclase inhibitory pathway pathway
PLC beta mediated events pathway
G-protein activation pathway
Opioid Signalling pathway
GABA B receptor activation pathway
Neuronal System pathway
Signaling by GPCR pathway
GABA receptor activation pathway
Platelet activation, signaling and aggregation pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Inhibition of adenylate cyclase pathway pathway
Signal amplification pathway
Hemostasis pathway
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Adenylate cyclase inhibitory pathway pathway
Platelet activation, signaling and aggregation pathway
Activation of GABAB receptors pathway
Inhibition of adenylate cyclase pathway pathway
G-protein activation pathway
ADP signalling through P2Y purinoceptor 12 pathway
GABA B receptor activation pathway
G alpha (z) signalling events pathway
GABA receptor activation pathway
G alpha (i) signalling events pathway
Neuronal System pathway
Opioid Signalling pathway
Signal Transduction pathway
Transmission across Chemical Synapses pathway
PLC beta mediated events pathway
Signal amplification pathway
G-protein mediated events pathway
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KEGG |
Gap junction pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Long-term depression pathway
Melanogenesis pathway
Parkinson's disease pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Gastric acid secretion pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Tight junction pathway
Axon guidance pathway
Melanogenesis pathway
Gap junction pathway
Leukocyte transendothelial migration pathway
Long-term depression pathway
Parkinson's disease pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Gastric acid secretion pathway
Toxoplasmosis pathway
Chagas disease (American trypanosomiasis) pathway
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INOH | |||||||||||||||||||||||
PID NCI |
SHP2 signaling
CXCR3-mediated signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | Q3ZCA7 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 539521 | ||||||||||||||||||||||
UniGene | Bt.49456 Bt.78340 | ||||||||||||||||||||||
RefSeq | NM_001034677 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | BC102645 BT030497 DAAA02007573 | ||||||||||||||||||||||
GenPept | AAI02646 ABQ12937 | ||||||||||||||||||||||
RNA Seq Atlas | 539521 | ||||||||||||||||||||||