Version 5.4
| Bos taurus Gene: AP2M1 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-635404.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | AP2M1 | ||||||||||||
| Gene Name | AP-2 complex subunit mu | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000020106 | ||||||||||||
| Encoded Proteins |
AP-2 complex subunit mu
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161203:
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 1:83583028-83591912 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Signaling by Wnt pathway
Signaling by EGFR pathway
Recycling pathway of L1 pathway
Trafficking of GluR2-containing AMPA receptors pathway
Retrograde neurotrophin signalling pathway
WNT5A-dependent internalization of FZD4 pathway
L1CAM interactions pathway
Immune System pathway
Transmission across Chemical Synapses pathway
Gap junction trafficking pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
Formation of annular gap junctions pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Axon guidance pathway
MHC class II antigen presentation pathway
beta-catenin independent WNT signaling pathway
Gap junction trafficking and regulation pathway
NGF signalling via TRKA from the plasma membrane pathway
PCP/CE pathway pathway
Neuronal System pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Signalling by NGF pathway
Adaptive Immune System pathway
EGFR downregulation pathway
Gap junction degradation pathway
Trafficking of AMPA receptors pathway
Disease pathway
Developmental Biology pathway
Membrane Trafficking pathway
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| KEGG | |||||||||||||
| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
MHC class II antigen presentation pathway
Retrograde neurotrophin signalling pathway
EGFR downregulation pathway
Signaling by EGFR pathway
Nef Mediated CD8 Down-regulation pathway
Nef Mediated CD4 Down-regulation pathway
Nef mediated downregulation of CD28 cell surface expression pathway
Formation of annular gap junctions pathway
Gap junction degradation pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
PCP/CE pathway pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Axon guidance pathway
Signal Transduction pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Gap junction trafficking pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
EPH-ephrin mediated repulsion of cells pathway
HIV Infection pathway
EPH-Ephrin signaling pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Gap junction trafficking and regulation pathway
Disease pathway
Membrane Trafficking pathway
Gap junction trafficking and regulation pathway
WNT5A-dependent internalization of FZD4 pathway
EGFR downregulation pathway
Disease pathway
Signaling by Wnt pathway
Recycling pathway of L1 pathway
Membrane Trafficking pathway
Formation of annular gap junctions pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
beta-catenin independent WNT signaling pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Immune System pathway
Retrograde neurotrophin signalling pathway
PCP/CE pathway pathway
MHC class II antigen presentation pathway
Gap junction degradation pathway
Signaling by EGFR pathway
Axon guidance pathway
L1CAM interactions pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Neuronal System pathway
Developmental Biology pathway
Trafficking of GluR2-containing AMPA receptors pathway
NGF signalling via TRKA from the plasma membrane pathway
Gap junction trafficking pathway
Signal Transduction pathway
Trafficking of AMPA receptors pathway
Transmission across Chemical Synapses pathway
Signaling by EGFR in Cancer pathway
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| KEGG |
Endocytosis pathway
Huntington's disease pathway
Huntington's disease pathway
Endocytosis pathway
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| INOH | |||||||||||||
| PID NCI |
Arf1 pathway
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | |||||||||||||
| UniGene | Bt.58835 Bt.88877 | ||||||||||||
| RefSeq | NM_001034523 XM_005201594 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | |||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | |||||||||||||