Version 5.4
Bos taurus Gene: BT.65140
Summary
InnateDB Gene IDBG-635448.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.65140
Gene Name alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019846
Encoded Proteins
IDBP-687284
alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189046:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66234084-66239899
Strand Forward strand
Band
Transcripts
ENSBTAT00000026442 ENSBTAP00000026442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734 DNA-N1-methyladenine dioxygenase activity
GO:0051747 cytosine C-5 DNA demethylase activity
Biological Process
GO:0006307 DNA dealkylation involved in DNA repair
GO:0035511 oxidative DNA demethylation
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000189046
View Gene Order
ENSMUSG00000044339
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_526
ABH2 mediated Reversal of Alkylation Damage pathway
REACT_127
DNA Damage Reversal pathway
REACT_2020
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_216
DNA Repair pathway
REACT_218005
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_219039
ABH2 mediated Reversal of Alkylation Damage pathway
REACT_233397
DNA Repair pathway
REACT_232874
DNA Damage Reversal pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N437
UniProt Splice Variant
Entrez Gene 511380
UniGene Bt.111474
RefSeq NM_001024516 XM_005217790 XM_005217791 XM_005217792
HUGO HGNC:32487
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045484
GenPept
RNA Seq Atlas 511380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca