InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.91781

Summary

InnateDB Gene

IDBG-635476.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.91781

Gene Name

retinal guanylyl cyclase 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008773

Encoded Proteins

IDBP-687326

retinal guanylyl cyclase 1 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132518:
This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:28274099-28288583

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011564

ENSBTAP00000011564

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016829	lyase activity
GO:0016849	phosphorus-oxygen lyase activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction