Homo sapiens Gene: ARAP1
Summary
InnateDB Gene IDBG-63550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAP1
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186635
Encoded Proteins
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72685069-72793599
Strand Reverse strand
Band q13.4
Transcripts
ENST00000334211 ENSP00000335506
ENST00000359373 ENSP00000352332
ENST00000393609 ENSP00000377233
ENST00000393605 ENSP00000377230
ENST00000452383 ENSP00000399118
ENST00000427971 ENSP00000411452
ENST00000455638 ENSP00000390461
ENST00000426523 ENSP00000392264
ENST00000429686 ENSP00000403127
ENST00000495878
ENST00000465814
ENST00000544721
ENST00000542596 ENSP00000441741
ENST00000536885 ENSP00000442746
ENST00000541623
ENST00000542612
ENST00000544958
ENST00000543868
ENST00000536993
ENST00000546293
ENST00000542264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0031702 type 1 angiotensin receptor binding
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008360 regulation of cell shape
GO:0030037 actin filament reorganization involved in cell cycle
GO:0032312 regulation of ARF GTPase activity
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051270 regulation of cellular component movement
GO:0051491 positive regulation of filopodium assembly
GO:0051497 negative regulation of stress fiber assembly
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
EGFR1 pathway
REACTOME
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
Regulation of RhoA activity
PDGFR-beta signaling pathway
Cross-References
SwissProt Q96P48
TrEMBL E7EU13 F5GWN4 F5GWQ2 F8WBT0
UniProt Splice Variant
Entrez Gene 116985
UniGene Hs.503165
RefSeq NM_001040118 NM_001135190 NM_015242
HUGO HGNC:16925
OMIM 606646
CCDS CCDS41687 CCDS44671 CCDS8217
HPRD
IMGT
EMBL AB018325 AB209473 AF411983 AJ621557 AP002381 AP003065 AY049732 AY553630 BC008315 BC021244 BC056401 BC140792
GenPept AAH08315 AAH56401 AAI40793 AAL04167 AAL12169 AAT36325 BAA34502 BAD92710 CAF21317
RNA Seq Atlas 116985