InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PER1

Summary

InnateDB Gene

IDBG-635565.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PER1

Gene Name

Uncharacterized protein

Synonyms

Rigui-like

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003889

Encoded Proteins

IDBP-687481

period homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:28390594-28399600

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005076

ENSBTAP00000005076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000989	transcription factor binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019900	kinase binding
GO:0031490	chromatin DNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002028	regulation of sodium ion transport
GO:0007165	signal transduction
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0010608	posttranscriptional regulation of gene expression
GO:0032922	circadian regulation of gene expression
GO:0042634	regulation of hair cycle
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070932	histone H3 deacetylation
GO:0097167	circadian regulation of translation
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway