Version 5.4
Bos taurus Gene: SELPLG
Summary
InnateDB Gene IDBG-635588.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELPLG
Gene Name P-selectin glycoprotein ligand 1 precursor
Synonyms SELPG
Species Bos taurus
Ensembl Gene ENSBTAG00000031851
Encoded Proteins
IDBP-687430
P-selectin glycoprotein ligand 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110876:
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66557143-66573393
Strand Forward strand
Band
Transcripts
ENSBTAT00000029578 ENSBTAP00000029577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050901 leukocyte tethering or rolling
GO:0050902 leukocyte adhesive activation
GO:0071354 cellular response to interleukin-6
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110876
View Gene Order
ENSMUSG00000048163
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05150
Staphylococcus aureus infection pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL F1MS77
UniProt Splice Variant
Entrez Gene 617434
UniGene Bt.6976
RefSeq NM_001037628 NM_001271160
HUGO HGNC:10722
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045491
GenPept
RNA Seq Atlas 617434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca