InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SERPINH1

Summary

InnateDB Gene

IDBG-635624.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINH1

Gene Name

Serpin H1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001027

Encoded Proteins

IDBP-687468

Serpin H1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149257:
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:55514945-55525175

Strand

Forward strand

Band

Transcripts

ENSBTAT00000039717

ENSBTAP00000039506

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0003433	chondrocyte development involved in endochondral bone morphogenesis
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030199	collagen fibril organization
GO:0032964	collagen biosynthetic process
GO:0051604	protein maturation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0070062	extracellular vesicular exosome