InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADRA1A

Summary

InnateDB Gene

IDBG-635639.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA1A

Gene Name

alpha-1A adrenergic receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031632

Encoded Proteins

IDBP-687482

alpha-1A adrenergic receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120907:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:75257161-75364423

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000044849

ENSBTAP00000042306

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0006937	regulation of muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007512	adult heart development
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0035265	organ growth
GO:0043410	positive regulation of MAPK cascade
GO:0045987	positive regulation of smooth muscle contraction
GO:0055117	regulation of cardiac muscle contraction
GO:0071875	adrenergic receptor signaling pathway
GO:0097195	pilomotor reflex