InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLEK

Summary

InnateDB Gene

IDBG-635678.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEK

Gene Name

pleckstrin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009658

Encoded Proteins

IDBP-687530

pleckstrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115956:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:66762701-66788487

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012724

ENSBTAP00000012724

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0002576	platelet degranulation
GO:0006904	vesicle docking involved in exocytosis
GO:0007229	integrin-mediated signaling pathway
GO:0010572	positive regulation of platelet activation
GO:0010920	negative regulation of inositol phosphate biosynthetic process
GO:0010925	positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0030030	cell projection organization
GO:0030836	positive regulation of actin filament depolymerization
GO:0030845	phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866	cortical actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0031532	actin cytoskeleton reorganization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0033625	positive regulation of integrin activation
GO:0035556	intracellular signal transduction
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488	phosphatidylinositol metabolic process
GO:0060305	regulation of cell diameter
GO:0070493	thrombin receptor signaling pathway
GO:0070527	platelet aggregation
GO:0070528	protein kinase C signaling
GO:0070560	protein secretion by platelet