InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STAT6

Summary

InnateDB Gene

IDBG-635695.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT6

Gene Name

signal transducer and activator of transcription 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006335

Encoded Proteins

IDBP-687680

signal transducer and activator of transcription 6, interleukin-4 induced

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17971840

[Homo sapiens] Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that mediates IL-13 cytokine signaling.

PMID 16433852

[Homo sapiens] STAT6 plays a role in the interleukin-4 (IL-4)-mediated modulation of TLR4 expression and the responsiveness of cells to lipopolysaccharide (LPS).

PMID 22000020

[Homo sapiens] STAT6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing. (Demonstrated in mice)

PMID 22000020

[Mus musculus] Stat6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing.

PMID 26953325

[Mus musculus] Stat6 signalling negatively regulates γδ17 T cells, which plays a front-line role in mucosal immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166888:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:56658077-56670842

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008311

ENSBTAP00000008311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002296	T-helper 1 cell lineage commitment
GO:0002829	negative regulation of type 2 immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0033598	mammary gland epithelial cell proliferation
GO:0035771	interleukin-4-mediated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0060443	mammary gland morphogenesis