InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: OGT

Summary

InnateDB Gene

IDBG-635754.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGT

Gene Name

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000902

Encoded Proteins

IDBP-687646

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147162:
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:84387999-84429228

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000045447

ENSBTAP00000042834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008047	enzyme activator activity
GO:0016262	protein N-acetylglucosaminyltransferase activity
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)
GO:0097363	protein O-GlcNAc transferase activity

Biological Process

GO:0006110	regulation of glycolytic process
GO:0006493	protein O-linked glycosylation
GO:0006915	apoptotic process
GO:0030854	positive regulation of granulocyte differentiation
GO:0031397	negative regulation of protein ubiquitination
GO:0032868	response to insulin
GO:0032922	circadian regulation of gene expression
GO:0035020	regulation of Rac protein signal transduction
GO:0043085	positive regulation of catalytic activity
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045862	positive regulation of proteolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046626	regulation of insulin receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0061087	positive regulation of histone H3-K27 methylation
GO:0071300	cellular response to retinoic acid
GO:0080182	histone H3-K4 trimethylation
GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070688	MLL5-L complex