Version 5.4
Bos taurus Gene: ANTXR1
Summary
InnateDB Gene IDBG-635770.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANTXR1
Gene Name anthrax toxin receptor 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007808
Encoded Proteins
IDBP-687667
anthrax toxin receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169604:
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67334898-67590481
Strand Forward strand
Band
Transcripts
ENSBTAT00000061292 ENSBTAP00000053745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0051015 actin filament binding
Biological Process
GO:0007165 signal transduction
GO:0022414 reproductive process
GO:0031532 actin cytoskeleton reorganization
GO:0034446 substrate adhesion-dependent cell spreading
Cellular Component
GO:0016021 integral component of membrane
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169604
View Gene Order
ENSMUSG00000033420
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BC74
UniProt Splice Variant
Entrez Gene 616010
UniGene Bt.91549
RefSeq NM_001206228 XM_005212883
HUGO HGNC:21014
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031515 DAAA02031516 DAAA02031517
GenPept
RNA Seq Atlas 616010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca