Bos taurus Gene: VAV3 | |||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-635847.3 | ||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
Gene Symbol | VAV3 | ||||||||||||||||||||||||||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000031575 | ||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
Uncharacterized protein
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134215:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 3:35428177-35861571 | ||||||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TCR pathway
RANKL pathway
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REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Regulation of actin dynamics for phagocytic cup formation pathway
GPVI-mediated activation cascade pathway
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Signaling by VEGF pathway
NRAGE signals death through JNK pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-ephrin mediated repulsion of cells pathway
GPVI-mediated activation cascade pathway
EPH-Ephrin signaling pathway
G alpha (12/13) signalling events pathway
VEGFR2 mediated vascular permeability pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Rho GTPase cycle pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Developmental Biology pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
FCERI mediated MAPK activation pathway
DAP12 interactions pathway
DAP12 signaling pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Fc epsilon RI signaling pathway pathway
Leukocyte transendothelial migration pathway
B cell receptor signaling pathway pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||||||||
PID NCI |
Regulation of RAC1 activity
Coregulation of Androgen receptor activity
Integrins in angiogenesis
Regulation of RhoA activity
Regulation of CDC42 activity
Osteopontin-mediated events
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Cross-References | |||||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||||
TrEMBL | E1BBD2 Q45KY0 | ||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
Entrez Gene | 521961 | ||||||||||||||||||||||||||||||||||||||||
UniGene | Bt.109707 Bt.110722 Bt.111065 | ||||||||||||||||||||||||||||||||||||||||
RefSeq | XM_002686162 XM_005204239 XM_615898 | ||||||||||||||||||||||||||||||||||||||||
HUGO | HGNC:12659 | ||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||
EMBL | DAAA02007603 DAAA02007604 DAAA02007605 DAAA02007606 DAAA02007607 DAAA02007608 DAAA02007609 DAAA02007610 DAAA02007611 DQ125496 | ||||||||||||||||||||||||||||||||||||||||
GenPept | AAZ38952 | ||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 521961 | ||||||||||||||||||||||||||||||||||||||||