Bos taurus Gene: ATP5B
Summary
InnateDB Gene IDBG-635890.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5B
Gene Name ATP synthase subunit beta, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013315
Encoded Proteins
ATP synthase subunit beta, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110955:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:57119917-57125290
Strand Forward strand
Band
Transcripts
ENSBTAT00000017710 ENSBTAP00000017710
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 79 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042288 MHC class I protein binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0006200 ATP catabolic process
GO:0006629 lipid metabolic process
GO:0006754 ATP biosynthetic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0015986 ATP synthesis coupled proton transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0046034 ATP metabolic process
GO:0051453 regulation of intracellular pH
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0042645 mitochondrial nucleoid
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Formation of ATP by chemiosmotic coupling pathway
Mitochondrial protein import pathway
Transcriptional activation of mitochondrial biogenesis pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Metabolism of proteins pathway
Metabolism pathway
Mitochondrial biogenesis pathway
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial biogenesis pathway
Formation of ATP by chemiosmotic coupling pathway
Metabolism of proteins pathway
Transcriptional activation of mitochondrial biogenesis pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Mitochondrial protein import pathway
Organelle biogenesis and maintenance pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Metabolism of proteins pathway
Mitochondrial protein import pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Transcriptional activation of mitochondrial biogenesis pathway
Mitochondrial biogenesis pathway
Formation of ATP by chemiosmotic coupling pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P00829
TrEMBL
UniProt Splice Variant
Entrez Gene 327675
UniGene Bt.4431
RefSeq NM_175796
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116099 M20929 X05605
GenPept AAA30395 AAI16100 CAA29094
RNA Seq Atlas 327675
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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