Version 5.4
Bos taurus Gene: MIP
Summary
InnateDB Gene IDBG-635918.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIP
Gene Name Lens fiber major intrinsic protein
Synonyms AQP0; MP22; MP26
Species Bos taurus
Ensembl Gene ENSBTAG00000010127
Encoded Proteins
IDBP-687795
Lens fiber major intrinsic protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135517:
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:57264365-57267776
Strand Forward strand
Band
Transcripts
ENSBTAT00000013360 ENSBTAP00000013360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015250 water channel activity
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006810 transport
GO:0006833 water transport
GO:0007601 visual perception
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135517
View Gene Order
ENSMUSG00000025389
View Gene Order
Pathways
NETPATH
REACTOME
REACT_216552
Aquaporin-mediated transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_208085
Passive transport by Aquaporins pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23826
Passive transport by Aquaporins pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_226335
Aquaporin-mediated transport pathway
REACT_259079
Passive transport by Aquaporins pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4516
RefSeq NM_173937
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca