Version 5.4
| Bos taurus Gene: MEFV | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-635925.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | MEFV | ||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000019123 | ||||||||||||
| Encoded Proteins |
Mediterranean fever
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Homo sapiens] MEFV inhibits the formation of CASP8, PYCARD and NLRC4 inflammasome formation by competing with CASP8 to bind to PYCARD.
[Homo sapiens] MEFV inhibits binding of NLRP3 with PYCARD.
[Homo sapiens] PYCARD-MEFV pyroptosome is induced by PSTPIP1 in a pyrin-dependent manner.
[Homo sapiens] MEFV homodimerization is important for its ability to induce PYCARD oligomerization and CASP1 activation.
[Homo sapiens] MEFV gene is bound constitutively by CEBPB, while RELA binds to the MEFV gene upon TNFA stimulation.
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| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103313:
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 25:2691854-2704324 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
The NLRP3 inflammasome pathway
Inflammasomes pathway
Innate Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
The NLRP3 inflammasome pathway
Inflammasomes pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
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| KEGG |
NOD-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | |||||||||||||
| UniGene | Bt.18827 | ||||||||||||
| RefSeq | |||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | |||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | |||||||||||||