InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NTN1

Summary

InnateDB Gene

IDBG-636006.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTN1

Gene Name

netrin-1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012137

Encoded Proteins

IDBP-687890

netrin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22231519

[Homo sapiens] NTN1 inhibits CCL2 and CCL19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall. (Demonstrated in mice)

PMID 22231519

[Mus musculus] Ntn1 inhibits Ccl2 and Ccl19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065320:
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:29084419-29269338

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016103

ENSBTAP00000016103

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030879	mammary gland development
GO:0033564	anterior/posterior axon guidance
GO:0040023	establishment of nucleus localization
GO:0042472	inner ear morphogenesis
GO:0045773	positive regulation of axon extension
GO:0060603	mammary gland duct morphogenesis