InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.38575

Summary

InnateDB Gene

IDBG-636010.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.38575

Gene Name

dysbindin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012939

Encoded Proteins

IDBP-687907

dysbindin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047579:
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:41076276-41165357

Strand

Forward strand

Band

Transcripts

ENSBTAT00000057192

ENSBTAP00000051067

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001956	positive regulation of neurotransmitter secretion
GO:0006996	organelle organization
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0010628	positive regulation of gene expression
GO:0014059	regulation of dopamine secretion
GO:0031175	neuron projection development
GO:0031532	actin cytoskeleton reorganization
GO:0048490	anterograde synaptic vesicle transport
GO:0048812	neuron projection morphogenesis
GO:0060155	platelet dense granule organization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016528	sarcoplasm
GO:0030424	axon
GO:0030426	growth cone
GO:0031083	BLOC-1 complex
GO:0042383	sarcolemma
GO:0043005	neuron projection
GO:0043197	dendritic spine