InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BDNF

Summary

InnateDB Gene

IDBG-636102.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BDNF

Gene Name

Brain-derived neurotrophic factor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008134

Encoded Proteins

IDBP-687996

Brain-derived neurotrophic factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176697:
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer\'s and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:59164541-59200908

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010694

ENSBTAP00000010694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001657	ureteric bud development
GO:0001662	behavioral fear response
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007406	negative regulation of neuroblast proliferation
GO:0007411	axon guidance
GO:0007412	axon target recognition
GO:0007611	learning or memory
GO:0007623	circadian rhythm
GO:0007631	feeding behavior
GO:0008038	neuron recognition
GO:0014047	glutamate secretion
GO:0016358	dendrite development
GO:0019222	regulation of metabolic process
GO:0021675	nerve development
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042490	mechanoreceptor differentiation
GO:0042493	response to drug
GO:0042596	fear response
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0046668	regulation of retinal cell programmed cell death
GO:0048167	regulation of synaptic plasticity
GO:0048675	axon extension
GO:0048839	inner ear development
GO:0051965	positive regulation of synapse assembly
GO:0060548	negative regulation of cell death
GO:0061193	taste bud development
GO:0097484	dendrite extension