InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SMARCC2

Summary

InnateDB Gene

IDBG-636219.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCC2

Gene Name

SWI/SNF complex subunit SMARCC2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014697

Encoded Proteins

IDBP-688140

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139613:
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:57467337-57484118

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019562

ENSBTAP00000019562

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.

Predicted by orthology
Total	111 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0043044	ATP-dependent chromatin remodeling
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0017053	transcriptional repressor complex
GO:0043234	protein complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex