Version 5.4
Bos taurus Gene: EEF1E1
Summary
InnateDB Gene IDBG-636313.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF1E1
Gene Name eukaryotic translation elongation factor 1 epsilon-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002534
Encoded Proteins
IDBP-688227
eukaryotic translation elongation factor 1 epsilon-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124802:
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:47219514-47235324
Strand Forward strand
Band
Transcripts
ENSBTAT00000003285 ENSBTAP00000003285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0005515 protein binding
Biological Process
GO:0006414 translational elongation
GO:0008285 negative regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000124802
View Gene Order
ENSMUSG00000001707
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3SZ15
UniProt Splice Variant
Entrez Gene 782393
UniGene Bt.48959
RefSeq NM_001040599
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103259 DAAA02055799
GenPept AAI03260
RNA Seq Atlas 617105 782393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca