InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAPK1

Summary

InnateDB Gene

IDBG-636344.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAPK1

Gene Name

death-associated protein kinase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000738

Encoded Proteins

IDBP-688366

death-associated protein kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196730:
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. [provided by RefSeq, Jul 2008]
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:82207240-82309507

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000982

ENSBTAP00000000982

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0017148	negative regulation of translation
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0071346	cellular response to interferon-gamma
GO:0097190	apoptotic signaling pathway
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity