InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BMP6

Summary

InnateDB Gene

IDBG-636350.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP6

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019234

Encoded Proteins

IDBP-688274

bone morphogenetic protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153162:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:47355128-47510231

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025614

ENSBTAP00000025614

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0046982	protein heterodimerization activity
GO:0070700	BMP receptor binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001654	eye development
GO:0001822	kidney development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001958	endochondral ossification
GO:0003323	type B pancreatic cell development
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030539	male genitalia development
GO:0032349	positive regulation of aldosterone biosynthetic process
GO:0040007	growth
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0060395	SMAD protein signal transduction