InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EDA

Summary

InnateDB Gene

IDBG-636361.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDA

Gene Name

Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form

Synonyms

ED1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012543

Encoded Proteins

IDBP-688277

Ectodysplasin-AEctodysplasin-A, membrane formEctodysplasin-A, secreted form

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158813:
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:85708003-86099973

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016649

ENSBTAP00000016649

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0006955	immune response
GO:0007160	cell-matrix adhesion
GO:0007275	multicellular organismal development
GO:0010467	gene expression
GO:0030154	cell differentiation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043473	pigmentation
GO:0043588	skin development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060662	salivary gland cavitation
GO:0060789	hair follicle placode formation
GO:0061153	trachea gland development
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045177	apical part of cell

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000158813

View Gene Order

ENSMUSG00000059327

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

mmu04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

Q9BEG5

TrEMBL

UniProt Splice Variant

Entrez Gene

616179

UniGene

Bt.101611

RefSeq

NM_001081743 XM_005228032 XM_005228033 XM_005228034 XM_005228035 XM_005228036

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ278907 AJ300468 AJ300469

GenPept

CAC29151 CAC29152

RNA Seq Atlas

616179