InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AR

Summary

InnateDB Gene

IDBG-636404.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

androgen receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000022255

Encoded Proteins

IDBP-688339

androgen receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169083:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:88410764-88621166

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000030067

ENSBTAP00000030053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 262 interaction(s) predicted by orthology.

Predicted by orthology
Total	262 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004882	androgen receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070974	POU domain binding

Biological Process

GO:0001701	in utero embryonic development
GO:0003073	regulation of systemic arterial blood pressure
GO:0003382	epithelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0009566	fertilization
GO:0009987	cellular process
GO:0010468	regulation of gene expression
GO:0019102	male somatic sex determination
GO:0030521	androgen receptor signaling pathway
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0033327	Leydig cell differentiation
GO:0035264	multicellular organism growth
GO:0043401	steroid hormone mediated signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0048608	reproductive structure development
GO:0048638	regulation of developmental growth
GO:0048645	organ formation
GO:0048808	male genitalia morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050790	regulation of catalytic activity
GO:0060520	activation of prostate induction by androgen receptor signaling pathway
GO:0060571	morphogenesis of an epithelial fold
GO:0060599	lateral sprouting involved in mammary gland duct morphogenesis
GO:0060685	regulation of prostatic bud formation
GO:0060736	prostate gland growth
GO:0060740	prostate gland epithelium morphogenesis
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0060748	tertiary branching involved in mammary gland duct morphogenesis
GO:0060749	mammary gland alveolus development
GO:0061458	reproductive system development
GO:0072520	seminiferous tubule development