InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.71689

Summary

InnateDB Gene

IDBG-636448.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.71689

Gene Name

claudin-11

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019060

Encoded Proteins

IDBP-688364

claudin-11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013297:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:97788089-97802992

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025374

ENSBTAP00000025374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007283	spermatogenesis
GO:0008366	axon ensheathment

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045178	basal part of cell
GO:0070062	extracellular vesicular exosome